It is known as a protein which is the most common cause of cancer, and is directly responsible for 30% of all diseases. Indirectly, involved in virtually all forms of this terrible disease.
cancer

For over 30 years scientists have tried unsuccessfully to find a way to control the protein known as Ras. Now, finally, scientists from the University of Toronto have managed to find a way to switch off Ras, using an experimental drug.

Their discovery could be a turning point in the fight against cancer.

“Scientists have known for decades trying to turn off the protein Ras,” said Professor Michael Ohh, School of Medicine of the University, and added, “But despite the effort, for years we did a lot of progress. In fact, called incurable protein “.

Uncontrolled cell growth

In normal circumstances, Ras stimulates cell growth, but protein also may cause uncontrolled growth of cells if mutated or deregulated becomes. It is therefore a key factor in many types of cancers and is mutated in 90% of cases of cancer of the pancreas, which is one of the deadliest forms of the disease.

OHH professor and his team have discovered that another protein, called SHP2, effective in excluding Breed.

“Our laboratory is known for another field of cancer biology. or a colleague’s request, we have entered into a field that deals with the Race of about five years ago to study mutations in rare form of pediatric leukemia. We were surprised when we discovered that no one had identified SHP2 as a trigger that regulates Ras, that it can control. ”

Working together with scientists from the Indiana University Health Network and from the University of Toronto, SHP2 team tested inhibitor in mice with glioblastoma, the most aggressive and the most common form of brain cancer.
Pancreatic cancer is particularly dangerous, and rarely survive one year with the disease

shocking progress

Scientists were shocked when they discovered that the inhibitor drug reduced tumors by more than 80%.
“The results of inhibitor were amazing, totally shocked us,” said Professor Ohh. “Nothing has had a similar effect.”

The next step will be testing the mice bearing human pancreatic tumor forms. If the SHP inhibitor proves effective, researchers will use this as evidence to enable further testing in humans.

“In addition to being a scientist, I am a gastroenterologist and I meet with a lot of patients with pancreatic cancer,” said Ioshihito Kano, co-author of the study. “These patients usually die within a year, even with chemotherapy, so that this drug could potentially change the lives of my patients.”

While their research is still in early stages, profesot Ohh and his team hope that their findings will open new perspectives and may change the way of treating cancer.

“If you better understand how the protein that causes cancer works, we hope to be able to control a lot better than before.

Finally, we wish that other scientists build on the basis of our findings, and thus give patients more options. ”

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It is known as a protein which is the most common cause of cancer, and is directly responsible for 30% of all diseases. Indirectly, involved in virtually all forms of this terrible disease. cancer For over 30 years scientists have tried unsuccessfully to find a way to control the protein known...